Paul Klenerman trained in medicine at the Universities of Cambridge and Oxford and specialised in infectious diseases.  He has been funded mainly by the Wellcome Trust,  initially working on HIV with Andrew McMichael and Rodney Phillips, then with Rolf Zinkernagel and Hans Hengartner in Zurich on LCMV and returning to Oxford to set up studies on T cells in chronic infections such as HCV. His group has in particular focused recently on MAIT cells and related cells and their role in response to viral infection and vaccines, and their biology in tissues, especially gut and liver.